Relaxing Mechanism of Gami-Shinkiwhan in Corpus Cavernosum Smooth Muscle
نویسندگان
چکیده
منابع مشابه
Experimental model of human corpus cavernosum smooth muscle relaxation.
PURPOSE To describe a technique for en bloc harvesting of the corpus cavernosum, cavernous artery and urethra from transplant organ donors and contraction-relaxation experiments with corpus cavernosum smooth muscle. MATERIALS AND METHODS The corpus cavernosum was dissected to the point of attachment with the crus penis. A 3 cm segment (corpus cavernosum and urethra) was isolated and placed in...
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Karkanis, Tom, Ling DeYoung, Gerald B. Brock, and Stephen M. Sims. Ca2 -activated Cl channels in corpus cavernosum smooth muscle: a novel mechanism for control of penile erection. J Appl Physiol 94: 301–313, 2003. First published September 27, 2002; 10.1152/japplphysiol.00660. 2002.—Little is known of the excitatory mechanisms that contribute to the tonic contraction of the corpus cavernosum sm...
متن کاملCa2+-activated Cl- channels in corpus cavernosum smooth muscle: a novel mechanism for control of penile erection.
Little is known of the excitatory mechanisms that contribute to the tonic contraction of the corpus cavernosum smooth muscle in the flaccid state. We used patch-clamp electrophysiology to investigate a previously unidentified inward current in freshly isolated rat and human corporal myocytes. Phenylephrine (PE) contracted cells and activated whole cell currents. Outward current was identified a...
متن کاملThe University of London the Investigation of Corpus Cavernosum Smooth Muscle Dysfunction in Low-flow Priapism
Prolonged low-flow (ischaemic) priapism results in a progressive alteration of the microenvironment within the corpus cavemosum with the development of hypoxia, acidosis and glucopenia and a reduction in the responsiveness to a-adrenergic receptor agonists. The aim of this study was to investigate the changes in the corporal microenvironment in patients presenting with refractory low-flow priap...
متن کاملPhenotypic Modulation of Corpus Cavernosum Smooth Muscle Cells in a Rat Model of Cavernous Neurectomy
BACKGROUND Patients undergoing radical prostatectomy (RP) are at high risk for erectile dysfunction (ED) due to potential cavernous nerve (CN) damage during surgery. Penile hypoxia after RP is thought to significantly contribute to ED pathogenesis. AIM We previously showed that corpora cavernosum smooth muscle cells (CCSMCs) undergo phenotypic modulation under hypoxic conditions in vitro. Her...
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ژورنال
عنوان ژورنال: Indian Journal of Science and Technology
سال: 2016
ISSN: 0974-5645,0974-6846
DOI: 10.17485/ijst/2016/v9i39/103234